Are Cholecalciferol and Ergocalciferol Interchangeable?

Although these two have historically been considered interchangeable and equipotent, the current body of literature strongly supports the preference of Vitamin D3 (cholecalciferol) over D2 (ergocalciferol).

Why do doctors prescribe vitamin D2 instead of D3?

What are vitamin D2 and vitamin D3 prescribed for? Vitamin D2 is indicated for rickets, hypoparathyroidism, and familial hypophosphatemia. In contrast, vitamin D3 is indicated for dietary supplementation (use as a vitamin).

Are vitamin D2 and vitamin D3 interchangeable?

It is available in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Key points: The pharmacopeiae consider these steroid hormones as equivalent and interchangeable. However, several studies have showed that serum level of 25(OH)D is increased more effectively with vitamin D3 than vitamin D2.

Marcus Vance

Marcus Vance

Cybersecurity & Digital Privacy Researcher

Marcus Vance is a cybersecurity auditor and technology writer dedicated to educating the public about online safety, data privacy regulations, enterprise security, and emerging cyber threats.