Are Mcgonagall and Filch Related?

I've noticed several people asking this question online. The answer is: NO.

Are Dumbledore and McGonagall related?

Harry Potter: 10 Reasons Why Minerva McGonagall & Albus Dumbledore Aren't Real Friends. ... Not only do they hold vital jobs at Hogwarts as the Transfiguration professor, head of Gryffindor, and the school's headmaster, the two are also supposedly close friends and allies.

Is Mrs Norris the wife of filch?

Mrs. Norris, the cat that everyone loves to hate, is really Filch's wife.