Are Protein Kinases Allosteric Effectors?

Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector molecules. Protein kinases catalyse the transfer of the terminal phosphate from ATP to protein substrates upon specific stimuli.

Is protein kinase A an effector?

Like other protein kinases, protein kinase A (also known as the cyclic AMP-dependent protein kinase or A kinase) is an enzyme that covalently decorates proteins with phosphate groups. ... This enzyme thus functions as the end effector for a variety of hormones that work through a cyclic AMP signalling pathway.

What is allosteric effector?

An allosteric effector is a molecule that binds to the site of an allosteric enzyme, causing a change in configuration resulting in an increase (positive effector) or reduction (negative effector) in enzyme activity. It is usually an intermediary in a metabolic pathway.