Are Proton Pump Inhibitors Safe

Although clinically important adverse effects of PPIs can occur, just as with other drugs, those are not frequently observed during or after administration. Thus, PPIs are regarded as relatively safe and considered to be clinically beneficial.

What are the long-term side effects of proton pump inhibitors?

Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B12 deficiency, chronic kidney disease, and dementia.

Are proton pump inhibitors bad for your heart?

Proton pump inhibitor use is independently associated with an increased incidence of heart failure and death. Proton pump inhibitors (PPIs) may increase the risk for heart failure and death, but not acute ischemic events, in patients with coronary artery disease (CAD), according to a study published in PLoS One.