Are Unfolded Proteins Stable?

The only factors affecting stability are the relative free energies of the folded (G_f) and the unfolded (G_u) states. The larger and more positive G_u, the more stable is the protein to denaturation.

Are folded or unfolded proteins more stable?

The protein is perfectly fine in its folded state, kept in an NMR tube for months on end. ... The protein's function does not require it to change shape - it simply binds its ligand CD58. It is stable with respect to unfolding or aggregation _under those conditions_.

What is the most stable form of protein?

The term native state is used to describe the protein in its most stable natural conformation in situ. This native state can be disrupted by several external stress factors including temperature, pH, removal of water, presence of hydrophobic surfaces, presence of metal ions and high shear.