Can Clindamycin Cause C Diff

Although most antibiotics can increase the risk of developing C. difficile colitis, clindamycin, fluoroquinolones, or cephalosporins are most highly associated with subsequent development of C. difficile infection (2).

Is clindamycin more likely to cause C. diff?

Without a doubt, clindamycin carries the highest risk of C difficile infection with an odds ratio of about 17-20 compared to no antibiotic exposure.

How long after taking clindamycin can you get C. diff?

Signs and symptoms usually develop within 5 to 10 days after starting a course of antibiotics. However, they may occur as soon as the first day or up to three months later.