Can Histoplasmosis Come Back?

If you've had histoplasmosis, you can get it again. However, if you do get it again, the illness will likely be milder the second time.

Can histoplasmosis reactivate?

A person who develops an immunosuppressive condition years after leaving the area of endemicity may reactivate a focus of infection and, through that mechanism, develop severe disseminated histoplasmosis (64, 80).

Can histoplasmosis recur?

If you've had histoplasmosis, you can get it again. However, if you do get it again, the illness will likely be milder the second time.