Can Inosine Pair with Guanine?

As a result, inosine forms base pairs with U and C as guanine does, and additionally base-pairs with A, which guanine cannot do because of a 2-amino group that is incompletely solvated in the context of the decoding center.

What does inosine base pair with?

Adenine is converted to adenosine or inosine monophosphate (IMP), either of which, in turn, is converted into inosine (I), which pairs with adenine (A), cytosine (C), and uracil (U).

Why is inosine read as guanine?

These structures can be edited by ADARs and the resulting inosine is interpreted as guanosine by the ribosome, because of its Watson–Crick base pairing with cytidine (see Figure 1).