Can Mandrake Get You High?

All species of Mandragora contain highly biologically active alkaloids, tropane alkaloids in particular. The alkaloids make the plant, in particular the root and leaves, poisonous, via anticholinergic, hallucinogenic, and hypnotic effects.

Which drug is made from mandrake?

Etoposide is a semisynthetic derivative of podophyllotoxin, a substance found naturally in the mandrake plant. Also known as VP-16, this epipodophyllotoxin is used in SCLC and NSCLC, among many others.

Can mandrake cause hallucinations?

Small quantities of mandrake may produce hallucinations or out of body experiences. However, this member of the nightshade family is highly toxic and all parts of the plant can be deadly.