Can Mononucleosis Cause Hepatitis?

Infectious mononucleosis due to Epstein-Barr virus (EBV) infection sometimes causes acute hepatitis, which is usually self-limiting with mildly elevated transaminases, but rarely with jaundice.

Can EBV cause hepatitis?

Acute hepatitis with icterus is a rare clinical manifestation in primary Epstein-Barr virus infection. Especially in older patients, Epstein-Barr virus infection can cause cholestasis; the diagnosis can be established by elimination of extrahepatic biliary obstruction.

How long does hepatitis from mono last?

The transmission is by contact with oral secretions. The incubation period is from 4 to 6 weeks and the symptoms usually last for 2 to 4 weeks. 1 Acute hepatitis by EBV infectious mononucleosis (IMN) presents with mildly elevated transaminases, but jaundice is a rare scenario.