Can Mosaicism Cause Death?

Mosaic mutations may cause cell-type-specific lethality (A); Mosaic loss of an essential juxtacrine signaling factor may cause localized death of cells that are not adjacent to unaffected tissues (B).

What are the consequences of mosaicism?

Chromosomal mosaicism, the presence of two or more distinct cell lines, is prevalent throughout human pre- and post-implantation development and can lead to genetic abnormalities, miscarriages, stillbirths or live births.

Why is mosaicism bad?

Mosaicism can low the accuracy of single cell PGD results. And it can happen even after the biopsy if the embryo was exposed to inadequate conditions. It is unlikely this group of embryo can implant.