Can Pantheon Block Pyke Ult?

According to Vandiril's Pantheon E interactions video, Pantheon blocks Pyke E damage only if he faces Pyke, and not when he faces Pyke's ghost.

What can pantheon not block?

1 Answer. Pantheon's passive will block champion basic attacks and turret shots, and any champion ability that applies on-hit effects. This includes things like Mystic Shot, and Gangplank's Parrrley. However, any on-hit effects of the attack still apply.

Does Pantheon E block for allies?

It blocks AOE abilities like fiddlesticks 'r', Anivia 'r', Karthus 'e', etc. as long as you activate your 'e' facing the enemy. The same thing applies to spells like Karthus 'r'.