Can Primary Amines Form Nitrosamines?

Primary, secondary and tertiary amines can all be nitrosated to generate nitrosamines. The secondary amines in general are the most reactive compounds towards nitrosating agents, generating nitrosamines. Primary alkyl amines react with nitrosating agents to give short-lived, highly reactive diazonium ions.

How is nitrosamine formed?

Nitrosamines are formed by reaction of secondary or tertiary amines with a nitrosating agent. In foods, the nitrosating agent is usually nitrous anhydride, formed from nitrite in acidic, aqueous solution. Food constituents and the physical make-up of the food can effect nitrosamine formation.

Is nitrosamine and aromatic amine?

N-nitrosamines are aliphatic or aromatic derivatives of secondary amines, which have a nitroso (–NO) group attached to nitrogen. They are formed by the reaction of nitrite with secondary amines. ... Many N-nitrosamines are strongly carcinogenic. They contaminate several foods, beverages, and water, at low levels.