Can Sasuke Use Totsuka Blade?

You can't.

Who can use the Totsuka blade?

This legend also holds very similar details to Itachi's final battle with Sasuke in Naruto when he fought against Orochimaru's Eight Branches Technique. Just like the legend, Itachi is able to use the Totsuka Blade to sever the heads of each snake before Orochimaru himself finally emerges with the Kusanagi Blade.

How strong is Totsuka blade?

Being a variant of the Sword of Kusanagi, this sword can cut through almost anything, as seen when Itachi easily decapitated seven of Orochimaru's eight-headed snake form.