Can Sotalol Be Crushed?

You can take sotalol with or without food. You can crush or cut the tablet. Take this drug in evenly spaced doses. If you're taking it two times per day, be sure to take it every 12 hours.

Is sotalol water soluble?

Sotalol hydrochloride is a white, crystalline solid with a molecular weight of 308.8. It is hydrophilic, soluble in water, propylene glycol and ethanol, but is only slightly soluble in chloroform.

How is sotalol administered?

Oral dosage of sotalol should be adjusted gradually allowing 2-3 days between dosing increments in order to attain steady-state, and to allow monitoring of QT intervals. Most patients respond to a daily dose of 160 to 320 mg administered in two divided doses at approximately 12 hour intervals.