Do Amines React with Carboxylic Acids?

The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate

the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 ^oC water is driven off and an amide is formed.

Can amide react with carboxylic acid?

Amides are carboxylic acid derivatives where the –OH of the carboxylic acid has been replaced by –NH₂, –NHR, or –NR₂ of an amine. Since the reaction between a carboxylic acid and an amine to give an amide also liberates water, this is an example of a “condensation reaction”.

What is the product of reaction of amines with carboxylic acids?

Reaction of amine with carboxylic acid at room temperature forms the ammonium carboxylate salt due to deprotonation of acid by the base. Amide is formed on heating of the ammonium carboxylate salt.