Do Antihistamines Affect Tryptase?

After the antihistamine treatment, tryptase values (M +/- SD: 4.4 +/- 1.8 micrograms/l) decreased significantly (p < 0.001). After the stop of antihistamine treatment, tryptase levels increased (M +/- SD: 5.5 +/- 2.6 micrograms/l, p < 0.001).

What can cause elevated tryptase?

Typically, there are increased numbers of mast cells in the bone marrow in this disease. Tryptase can also be elevated with asthma, myelodysplastic syndrome (a type of bone marrow disorder), acute myelocytic leukemia, and with any condition that activates mast cells.

Can you have mastocytosis with normal tryptase?

Although, serum tryptase is often used as a screening tool for systemic mastocytosis, it can be normal in about 10% of patients.