Do B Cells Undergo Clonal Selection

B cells primarily function to make antibodies against antigens, act as antigen-presenting cells (APCs), and eventually develop into memory B cells to provide long-term immunity. B cells undergo clonal selection and develop similarly to T cells with some notable differences.

Do B cells undergo selection?

Both B and T cells undergo positive and negative selection in the primary lymphoid organs. Positive selection requires signaling through the antigen receptor for the cell to survive. Developing B cells are positively selected when the pre-B receptor binds its ligand.

How are B cells recruited?

B cells recruit Th2 cells to receive stimuli Upon activation, naïve B cells express CCL17 and CCL22. These chemokines recruit CD4+CCR4+ Th2 T cells that provide B cells with appropriate cues to differentiate and produce cytokines.