Do Cymbalta Side Effects Subside?

Duloxetine normally takes 2 to 4 weeks to work. It may take longer if you're taking it for nerve pain. Common side effects include feeling sick, a dry mouth, headache, constipation and feeling sleepy. These side effects are usually mild and go away after a couple of weeks.

How long does it take to adjust to Cymbalta?

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.

Does Cymbalta make you feel worse before better?

Some patients may feel worse instead of better when first starting drugs like Cymbalta or when changing the dose. You may feel more anxious, agitated, hostile, aggressive, impulsive, and feel like you are not yourself or become less inhibited. You may have thoughts of suicide, hurting yourself or other people.