Do Enzyme Inducers Increase Liver Enzymes?

For example, in addition to being inhibitors of CYP3A4, ritonavir and NFV are moderate hepatic enzyme inducers. They can increase activity of so-called phase 2 enzymes such as hepatic glucuronosyl transferase, as well as CYP.

What do enzyme inducers do?

An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. It is the opposite of an enzyme repressor.

What are liver enzyme inducers?

Certain medicines used to treat epilepsy, HIV, tuberculosis and the herbal medicine, St John's Wort are known as liver enzyme inducers.