Do Platelets Release Thrombin?

Thrombin is also key mediator of platelet activation, release reaction and aggregation. Its action on platelets produces a highly efficient catalytic surface for further generation of thrombin.

Do platelets generate thrombin?

Although platelets could not contains TF, they can generate thrombin through a TF independent mechanism [2]. Because TF expression by vascular cells induces intravascular thrombosis [9], in this study, we used an intrinsic coagulation system, lacking external TF.

What do platelets release?

Platelets secrete many factors involved in coagulation and wound healing. During coagulation, they release factors that increase local platelet aggregation (thromboxane A), mediate inflammation (serotonin), and promote blood coagulation through increasing thrombin and fibrin (thromboplastin).