Do Ppis Cause Hypocalcemia?

Short-term use of PPIs may precipitate acute hypocalcemia in patients with hypoparathyroidism through direct (reduced calcium absorption) or indirect (hypomagnesemia and PTH inhibition) pathways. In patients with low PTH, anti-acid use should be done cautiously.

Can omeprazole cause hypocalcemia?

In 2008, Agarwal et al. 3) reported a case of 3 years of omeprazole treatment developing hypomagnesemia and hypocalcemia which magnesium and calcium replacement would not resolve symptoms and serum level. Oral supplement of magnesium and calcium were only partially effective while PPI treatment is maintained.

Why does PPI cause hypocalcemia?

Hypocalcemia is common in such cases and is a result of the functional hypoparathyroidism that is thought to be induced by severe hypomagnesemia. It is thought that PPI drugs impair active and passive absorption of dietary magnesium, and hypomagnesemia is a cumulative effect of prolonged PPI use.