Do Proton Pump Inhibitors Affect Iron Absorption

Taken together, PPIs directly affect iron metabolism by suppressing iron absorption through the inhibition of duodenal ferroportin via hepcidin upregulation. These findings provide a new insight into the molecular mechanism of PPI-induced iron deficiency.

Can PPIs cause iron deficiency?

Although the long-term use of PPIs is considered safe, there are several reported cases of iron deficiency anemia due to PPI use (2-4) and a community-based case control study reported that the risk of iron deficiency was increased among long-term PPI users (5).

What medications affect iron absorption?

• Tetracyclines: Antibiotics that include doxycycline (Vibramycin), minocycline (Minocin), and tetracycline.
• Quinolones: Antibiotics that include ciprofloxacin (Cipro), norfloxacin (Noroxin), and levofloxacin (Levaquin).