Do Suppositories Avoid First-Pass Metabolism?

Alternative routes of administration

routes of administration

Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration. Routes can also be classified based on where the target of action is.

› wiki › Route_of_administration

, such as insufflation, suppository, intravenous, intramuscular, inhalational aerosol, transdermal, or sublingual, avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation.

Which drug can not give by oral route due to first-pass metabolism?

Commonly used drugs that undergo extensive first pass metabolism are cimetidine, lidocaine, propranolol, nitroglycerin, diazepam, midazolam, morphine, pethidine, imipramine, and buprenorphine. Some drugs like insulin are destroyed by the gastric secretions and therefore cannot be given orally.

What route of administration of medication avoids first-pass metabolism?

Intravenous (IV)

Injection straight into the systemic circulation is the most common parenteral route. It is the fastest and most certain and controlled way. It bypasses absorption barriers and first-pass metabolism.