Do Tcas Cause Hyponatremia?

The initial reports of antidepressants associated with hyponatremia concerned TCA, but only a few later studies have compared the incidence of hyponatremia in TCAs with other antidepressants. In a large register-based study, Coupland et al found a weaker association between hyponatremia and TCAs compared to SSRIs.

Do tricyclic antidepressants cause hyponatremia?

Mirtazapine and tricyclic antidepressants showed a moderate risk of hyponatremia, supporting the use of these drugs as alternative therapy for patients at an increased risk for hyponatremia. Due to insufficient data, the risk associated with MAO inhibitors and bupropion could not be established.

Do antipsychotics cause hyponatremia?

The use of antipsychotic medications may put patients with schizophrenia at an increased risk of developing hyponatremia.