Does Acetylcholine Cause Vasodilation?

Acetylcholine (ACh) can effect vasodilation by several mechanisms, including activation of endothelial nitric oxide (NO) synthase and prostaglandin (PG) production. In human skin, exogenous ACh increases both skin blood flow (SkBF) and bioavailable NO levels, but the relative increase is much greater in SkBF than NO.

Is acetylcholine a vasoconstrictor or vasodilator?

Acetylcholine, believed to be an endothelial-dependent vasodilator, acted as a potent vasoconstrictor when it was infused into the diseased coronary arteries of eight patients with advanced stenoses.

Does acetylcholine cause vasoconstriction or vasodilation?

In various vascular beds, acetylcholine has been reported to evoke vasodilation in endothelium-intact and vasoconstriction in endothelium-damaged blood vessels.