Does Buprenorphine Increase Transaminases?

In a small open study, 70% of patients on 8 mg sublingual buprenorphine showed a distinct increase in aspartate aminotransferase (AST) alanine aminotransferase (ALT), although most still remained in the normal range and it could not be certain that buprenorphine was the cause (50).

Does buprenorphine cause elevated transaminase?

Elevated transaminases have also been observed in patients with a history of liver disease who were treated with therapeutic doses of sublingual buprenorphine (Petry et al., 2000).

Does buprenorphine cause elevated liver enzymes?

Therapy with buprenorphine is associated with mild and transient serum enzyme elevations, and with moderate-to-severe clinically apparent liver injury when abused by intravenous administration or the sublingual formations.