Does Close Shot Affect Layups?

Yes, Close Shot is used for Standing Layups.

Does close shot affect layups and dunks?

Re: Does Shot Close or anything else affect dunks/layups? Shot Close does not affect dunks. But it could affect particular layups if they're released far enough from the hoop.

What does close shot affect in 2k21 Next Gen?

Close shot is tied up to your post hooks and it covers whatever shots taken on that close zone and that includes post fades, standing layups, and whatever as long as they were taken on that spot.