Does Diffusion Move Through the Phospholipid Bilayer?

The simplest mechanism by which molecules can cross the plasma membrane is passive diffusion. During passive diffusion, a molecule simply dissolves in the phospholipid bilayer, diffuses across it, and then dissolves in the aqueous solution at the other side of the membrane.

What can diffuse through the phospholipid bilayer?

Permeability of phospholipid bilayers. Small uncharged molecules can diffuse freely through a phospholipid bilayer. However, the bilayer is impermeable to larger polar molecules (such as glucose and amino acids) and to ions.

Does diffusion pass between phospholipids?

In simple diffusion, the substance passes between the phospholipids; in facilitated diffusion there are a specialized membrane channels. Charged or polar molecules that cannot fit between the phospholipids generally enter and leave cells through facilitated diffusion.