Does Naltrexone Block Cannabinoid Receptors?

James H. Sterling
James H. Sterling
• • 6 min read

For Example, the Opioid Antagonist Opioid Antagonist Naloxone and Naltrexone Are Commonly Used Opioid Antagonist Drugs Which Are Competitive Antagonists That...

Does Naltrexone Block Cannabinoid Receptors?

For example, the opioid antagonist

opioid antagonist
Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors. This effectively blocks the receptor, preventing the body from responding to opioids and endorphins.
› wiki › Opioid_antagonist
, naltrexone, did not alter cannabinoid analgesia (Greenwald and Stitzer, 2000), and did not antagonize the subjective, reinforcing or physiological effects of THC in human marijuana smokers
marijuana smokers
Cannabis smoking (or colloquially smoking pot) is the inhalation of smoke or vapors released by heating the flowers, leaves, or extracts of cannabis and releasing the main psychoactive chemical, Δ9-tetrahydrocannabinol (THC), which is absorbed into the bloodstream via the lungs.
› wiki › Cannabis_smoking
(Wachtel and de Wit, 2000; Haney et al, 2003).

Does naltrexone affect CBD?

In summary, the results indicate that combining low doses of CBD plus naltrexone has a greater efficacy at reducing ethanol consumption and the motivation to drink that either drug administered alone.

Must Read

What receptors does naltrexone use?

Naloxone is a competitive antagonist at μ-, δ-, κ-, and σ-opioid receptors and acts to reverse the effects of most opioid analgesics.

James H. Sterling

James H. Sterling

Environmental Science & Climate Journalist
Twitter Linkedin

James Sterling reports on renewable energy developments, climate policy, ecological conservation, and green tech innovations around the globe.