Does Vitamin D Stimulate Osteoblasts?

Vitamin D effects on differentiation and mineralization are mostly stimulatory in human and rat osteoblasts, and inhibitory in murine osteoblasts.

Does vitamin D increased osteoclast activity?

In co-culture studies of osteoblasts and hematopoietic cells, active metabolites of vitamin D has been shown to stimulate osteoclastogenesis. This stimulation has been shown to be an increase in RANKL production and consequently osteoclast stimulation.

Does vitamin D activate osteoblast?

Active vitamin D compounds stimulate osteoclast formation in a co-culture of osteoblastic cells and hematopoietic cells. Osteoblastic cells express RANKL in response to 1α,25(OH)₂D₃.