Does Vitrase Need to Be Diluted?

Vitrase is to be reconstituted in the vial to a concentration of 1000 Units/mL of Sodium Chloride Injection, USP by adding 6.2 mL of solution to the vial. Prior to administration, the reconstituted solution should be further diluted to the desired concentration, commonly 150 Units/mL, see table below.

How do you inject vitrase?

Insert needle with aseptic precautions. With tip free and movable between skin and muscle, begin clysis; fluid should start in readily without pain or lump. Then inject VITRASE (hyaluronidase injection) into rubber tubing close to needle. An alternate method is to inject VITRASE under skin prior to clysis.

How do you dilute Hyalase?

There is 1500 IU in one vial hyalase. Dilute with 5ml saline: Do this by drawing up 5 ml of saline from the 30 ml bottle. Put 1 ml of the 5ml into the hyalase vial, dissolve thoroughly and then draw up the solution, make sure the powder is fully dissolved.