Does Zyprexa Cause Hyponatremia

Rapid-onset hyponatremia is a rare, but potential, complication of olanzapine treatment. Hyponatremia, secondary to atypical antipsychotic use, has been reported in many case reports and is thought to be associated with a syndrome of inappropriate anti-diuretic hormone secretion (SIADH).

Does olanzapine affect sodium levels?

Clinicians should be aware that patients being treated with Olanzapine can develop hyponatraemia and it is important to check serum sodium levels when patients on Olanzapine develop symptoms suggestive of hyponatraemia.

What psych meds can cause hyponatremia?

Atypical antipsychotics (aripiprazole, quetiapine, clozapine) cause hyponatremia due to their serotonin-mediated effects on central 5-HT2 and 5-HT1c receptors which lead to excess release of ADH. Furthermore, serotonin is known to reset the osmostat and thereby lowers the threshold for ADH secretion.