For Base Excision Repair?

Proteins involved in base excision repair
  • DNA glycosylases.
  • AP endonucleases.
  • End processing enzymes.
  • DNA polymerases.
  • Flap endonuclease.
  • DNA ligase.
  • MBD4.
  • NEIL1.

What are the steps in base excision repair?

The repair process takes place in five core steps: (1) excision of the base, (2) incision, (3) end processing, and (4) repair synthesis, including gap filling and ligation.

What is base excision repair and what is it used for?

Base excision repair (BER) corrects small base lesions that do not significantly distort the DNA helix structure. It is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site which is further processed by short-patch repair or long-patch repair.

Elena Rostova

Elena Rostova

Lead Health, Wellness & Medical Journalist

Elena Rostova holds a Master's degree in Public Health Journalism. She covers groundbreaking medical research, holistic wellness trends, mental health awareness, and nutritional science.