Has Sertraline Got a Sedative in It?

At clinical doses, sertraline blocks the uptake of serotonin into human platelets. It is devoid of stimulant, sedative or anticholinergic activity or cardiotoxicity in animals. In controlled studies in normal volunteers, sertraline did not cause sedation and did not interfere with psychomotor performance.

Does sertraline make you sleepy?

You can feel drowsy in the first few days of taking sertraline. This should get better after the first week or two. If it makes you feel drowsy, try taking it just before you go to bed. You could also, strangely, get insomnia (difficulty getting to sleep), and disturbing dreams or nightmares.

Does Zoloft have sedation?

A case study reported that people who took Zoloft could experience drowsiness and sedation from the drug. The risk of drowsiness is higher if you take larger doses of Zoloft, such as 100 milligrams (mg). However, Zoloft can cause drowsiness at any dosage.