How Do Imids Work?
Imids Inhibits Endothelial Sprout Formation and Vessel Migration in Vitro Models. Anti-Angiogenesis Occurs via Modulation of Chemotactic Factors Involved in...
IMiDs inhibits endothelial sprout formation and vessel migration in vitro models. Anti-angiogenesis occurs via modulation of chemotactic factors involved in endothelial cell migration including TNFa, VEGF and βFGF secreted by BMSC, rather than direct inhibition of endothelial cell proliferation.
How does an immunomodulator work?
Immunomodulators work by suppressing or weakening a patient's immune system in order to reduce inflammation and the symptoms it causes. However, they can also have the effect of decreasing the body's ability to combat infection.
What is lenalidomide mechanism of action?
Mechanism of action
In vivo, lenalidomide induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.
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