How Do Polyenes Work
The Polyene Drugs Work by Interacting with Ergosterol, a Type of Steroid That Is Found in Fungal Membranes; This Binding Causes Channels to Form in the Fungal...
The polyene drugs work by interacting with ergosterol, a type of steroid that is found in fungal membranes; this binding causes channels to form in the fungal membrane, resulting in the loss of membrane-selective permeability and of cytoplasmic components.
What is the mechanism of action of Polyenes?
Mechanism of action Polyenes bind to ergosterol in the cell membrane of fungi and form aqueous pores that promote leakage of intracellular ions and disrupt active transport mechanisms dependent on membrane potential. They can be fungistatic or fungicidal.
How are Polyenes administered?
They are not absorbed when given orally, so are used to treat fungal infections of the gastrointestinal tract, such as oral thrush. For treatment of systemic fungal infections they need to be administered intravenously.
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