How Do Prostaglandins Cause Inflammation

Prostaglandins play a key role in the generation of the inflammatory response. Their biosynthesis is significantly increased in inflamed tissue and they contribute to the development of the cardinal signs of acute inflammation.

Why do prostaglandins cause inflammation?

Prostaglandins play a key role in the generation of the inflammatory response. Their biosynthesis is significantly increased in inflamed tissue and they contribute to the development of the cardinal signs of acute inflammation.

How do prostaglandins create inflammation?

High concentrations of prostaglandins cause pain by direct action upon nerve endings. More typically, however, at low concentrations, they markedly increase sensitivity to pain. The pain threshold may be so altered that even normally painless stimuli may be painful.