How Do Sulfonamides Inhibit Folate Synthesis
By Virtue of Their Chemical Resemblance to P-Aminobenzoate, Sulfonamides Inhibit the Synthesis of Folates by Blocking the Conversion of Paba to Dihydrofolic...
By virtue of their chemical resemblance to p-aminobenzoate, sulfonamides inhibit the synthesis of folates by blocking the conversion of PABA to dihydrofolic acid.
How do sulfa drugs inhibit folic acid synthesis?
Sulfa drugs work by binding and inhibiting a specific enzyme called dihydropteroate synthase (DHPS). This enzyme is critical for the synthesis of folate, an essential nutrient. Mammals get folate from their diet, but bacteria must synthesize this vitamin.
How the inhibition of folic acid production is carried out by sulfanilamide?
Sulfonamides belong to the non-classical antifolates group and are the ones that inhibit DHPS by penetrating into the PABA pocket of the enzyme, avoiding the entrance of PABA to the reaction site and forming an analog that cannot be used as a subtract in the following reaction of the folate cycle [8].
Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.
