How Does Acyl-Coa Get Across the Inner Mitochondrial Membrane

Fatty acyl CoA is impermeable to the inner mitochondrial membrane, so it is carried in the form of fatty acyl carnitine. Fatty acyl carnitine is transported across the inner mitochondrial membrane in exchange for carnitine by an antiport translocase.

How does acyl CoA enter the mitochondria?

Acetyl-CoA is first made in the mitochondria either by the removal of hydrogen from a molecule pyruvate or by the oxidation of other fatty acids. This is a delicate balancing act. … Acetyl-CoA is moved through the mitochondrial membrane, and enters the cytoplasm of the cell, as the molecule citrate.

Can Acetyl-CoA cross mitochondrial membrane?

Acetyl-CoA must cross the mitochondrial membrane to the cytosol, where fatty acid synthesis takes place. Acetyl-CoA is combined with oxalacetic acid by the enzyme citrate synthase, creating citric acid. … Pyruvate can then be transported back into the mitochondria and undergo decarboxylation into oxalacetic acid.