How Does Aromatization Happen?

Aromatization occurs when the aromatase complex converts C19 androgen substrates to C18 estrogens in three consecutive reactions: (1) hydroxylation (2) oxidation and (3) demethylation.

What triggers the production of estrogen?

GnRH stimulates the pituitary gland to produce follicle stimulating hormone (FSH), the hormone responsible for starting follicle (egg) development and causing the level of estrogen, the primary female hormone, to rise.

What increases aromatase?

Aromatase activity appears to be enhanced in certain estrogen-dependent local tissue next to breast tissue, endometrial cancer, endometriosis, and uterine fibroids.

Alexander Ross

Alexander Ross

Gaming, Esports & Interactive Media Writer

Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.