How Does Disintegration Work?
Disintegration Is Achieved by the Penetration of the Physiological Fluid into the Powder Compact and the Subsequent Disruption of the Particle-Particle Bonds...
Disintegration is achieved by the penetration of the physiological fluid into the powder compact and the subsequent disruption of the particle-particle bonds which maintain the structural integrity of the dosage form.
What is disintegration process?
Disintegration is defined as that state in which no residue of the unit under test remains on the screen of the apparatus or, if a residue remains, it consists of fragments of disintegrated parts of tablets component parts such as insoluble coating of the tablets or of capsule shells, or of any melted fatty substance ...
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What causes tablet disintegration?
The mechanism of immediate release from porous tablets can be attributed to quick entry of water into porous matrix which causes rapid disintegration and dissolution of the tablet. The oral bioavailability of poorly water-soluble drugs is enhanced by porous compacts.
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