How Does Finerenone Work?

Finerenone acts as an antagonist to mineralocorticoid receptors harboring the S810L mutation, unlike other traditional MR inhibitors such as spironolactone and eplerenone that incidentally act as agonists.

How is finerenone different than spironolactone?

It has a better selectivity than spironolactone and a better affinity than eplerenone. Finerenone has a more favorable balance between and renal side effects, especially in populations prone to hyperkalemia such as patients with chronic kidney disease or diabetes.

Does finerenone lower blood pressure?

Finerenone is a non-steroidal mineralocorticoid receptor blocker, which means its chemistry is very different, pharmacokinetics are very different, and frankly, its clinical properties and effects are very different. Finerenone does not lower blood pressure, not significantly, 1 millimeter.