How Does Prb Work?

pRb binds to DNA-bound E2F transcriptional regulators and suppresses their target gene expression through recruitment of HDACs, co-repressors, and chromatin remodeling enzymes. It also serves to inhibit the binding of co-activating transcription factors to E2F-bound promoters.

What is the function of pRb?

pRB, the tumor suppressor product of the retinoblastoma susceptibility gene, is regarded as one of the key regulators of the cell cycle. This protein exerts its growth suppressive effect through its ability to bind and interact with a variety of cellular proteins.

How is pRb activated?

Activation/ Deactivation of pRB

Activation of retinoblastoma protein occurs when it is hypophosphorylated, bound to E2F, and is not mutated. When hypophosphorylated, it inactivates cdk-cyclin complexes and is tightly bound to E2F. A non mutated pRb protein can undergo proper phosphorylation and proper binding to E2F.