How Does Renal Autoregulation Work?

Autoregulation is a fundamental component of renal function. It integrates intrinsic intrarenal mechanisms that stabilize RBF and glomerular filtration rate (GFR) during changes in renal perfusion pressure (RPP) over a defined range.

What is renal autoregulation?

INTRODUCTION. Renal blood flow (RBF) autoregulation is a vital homeostatic mechanism that protects the kidney from elevations in arterial pressure that would be transmitted to the glomerular capillaries and cause injury.

How does autoregulation occur?

Autoregulation is a manifestation of local blood flow regulation. ... When blood flow falls, arterial resistance (R) falls as the resistance vessels (small arteries and arterioles) dilate. Many studies suggest that that metabolic, myogenic and endothelial mechanisms are responsible for this vasodilation.