How Does Terlipressin Reduce Portal Pressure

12 Terlipressin acts on V1 receptors to cause splanchnic vasoconstriction, which reduces portal inflow and pooling of blood in the splanchnic circulation. This results in reduced portal pressure and improved renal perfusion.

What is the mechanism of action of terlipressin?

Terlipressin selectively causes splanchnic and extrarenal vasoconstriction by stimulation of V1 receptors, which are predominantly located in the smooth muscles of the arterial vasculature in the splanchnic region and thereby reduces splanchnic blood flow and portal pressure.

How can portal pressure be reduced?

Medications such as propranolol and isosorbide may be prescribed to lower the pressure in the portal vein and reduce the risk of recurrent bleeding. The drug lactulose can help treat confusion and other mental changes associated with encephalopathy.