How Fluoroquinolones Affect and Destroy Bacteria?

A fluoroquinolone is an antibiotic that destroys bacteria by interfering with its DNA replication. Early generation fluoroquinolones hamper bacterial DNA synthesis during replication primarily by inhibiting DNA gyrase, one enzyme required for bacterial (but not human) DNA replication.

Where do fluoroquinolones affect and destroy bacteria?

The newer fluoroquinolones are a major advance in antimicrobial chemotherapy. They inhibit the supercoiling activity of the DNA gyrase enzyme, thus exerting their antibacterial action on DNA and RNA synthesis, resulting in a biphasic response and killing of susceptible organisms.

Do fluoroquinolones kill bacteria?

In summary, these results indicate that the rate of killing by fluoroquinolones is bacterial group dependent. Fluoroquinolones kill gram-negative bacteria more rapidly than staphylococci. Quinolones killed nonstreptococcal strains more rapidly than did β-lactams and vancomycin.