How Is Fosamax Metabolized
Preclinically, Alendronate Is Not Metabolised in Animals and Is Cleared from the Plasma by Uptake into Bone and Elimination via Renal Excretion. Although Soon...
Preclinically, alendronate is not metabolised in animals and is cleared from the plasma by uptake into bone and elimination via renal excretion. Although soon after administration the drug distributes widely in the body, this transient state is rapidly followed by a nonsaturable redistribution to skeletal tissues.
Is Fosamax bad for kidneys?
To minimize the risk of chronic kidney disease (CKD) progressing to end-stage renal disease (ESRD), such osteoporosis medications as alendronate (Fosamax) and ibandronate (Boniva) are contraindicated in individuals whose glomerular filtration rate (GFR) is <30%.
Where is Fosamax absorbed by the body?
Our data suggest that in patients with Crohn’s disease, alendronate is adequately absorbed from the intestine and retained in the skeleton. This adequacy is confirmed by appropriate suppression of bone resorption and increase in lumbar spine BMD.
Elena Rostova holds a Master's degree in Public Health Journalism. She covers groundbreaking medical research, holistic wellness trends, mental health awareness, and nutritional science.
