How Is Malignant Hyperthermia Detected

The abnormal gene that makes you susceptible to malignant hyperthermia is identified using genetic testing. A sample of your blood is collected and sent to a lab for analysis. Genetic testing can reveal changes (mutations) in your genes that may make you susceptible to malignant hyperthermia.

How is MH tested?

The caffeine halothane contracture test (CHCT) is the criterion standard for establishing the diagnosis of malignant hyperthermia (MH). The test is performed on freshly biopsied muscle tissue at 30 centers worldwide; one of these centers is located in Canada, and four are located in the United States.

What laboratory test are monitored during an acute MH episode?

Monitor blood gases, core temperature, creatine kinase (CK), urine output, urine color, electrolytes, coagulation parameters, and treat abnormalities as needed. Treat cardiac arrhythmias, which are usually responsive to correction of acidosis and hyperkalemia.