How Is Sodium Cyclamate Made

Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide.

Why is sodium cyclamate banned in USA?

Cyclamates were banned by the FDA as a food ingredient in 1969 because the saccharin/cyclamate mixture was shown to cause cancer in experimental laboratory rats. The primary concern was that it could be toxic to some individuals who appear to metabolize cyclamate to cyclohexylamine.

Does sodium cyclamate cause cancer?

After reexamination of cyclamate’s carcinogenicity and the evaluation of additional data, scientists concluded that cyclamate was not a carcinogen or a co-carcinogen (a substance that enhances the effect of a cancer-causing substance).